The fact that 4 billion people globally suffering from severe water scarcity has made the reverse-osmosis (RO) membrane technique the dominant process for clean water production, currently generating 100 million tons of desalinated water per day from the Oceans. Its high energy consumption however limits its widespread adoption, but in the meantime also motivated researchers to develop synthetic water channels for blending into RO membrane to decrease the water desalination pressure and consequently reduce the energy consumption. For this purpose, unifying high water permeability and selectivity in one simplified water channel system is an indispensable prerequisite, which is and so far proves to be challenging. Recently, we made some encouraging discovery, via a “sticky” end-mediated construction strategy (see: J. Am. Chem. Soc. 2014, 136, 14270 and Acc. Chem. Res. 2016, 49, 922), of a novel synthetic water channel that displays high water transport (~ 3 x 109water molecules/s) and high rejection of salts such as NaCl and KCl. (J. Am. Chem. Soc. 2020, 142, 10050; Angew. Chem. Int. Ed. 2020, 59, 13328), and has met application parameter requirements. More recently, we devised another completely different and novel type of polymer-based water channels that increases the water transport permeability by 8-fold to 2.7 x 1010 water molecules/s (Nat. Nanotech. 2021, 16, 911). While striving to further improve their water transport properties, we are now attempting to find different ways of blending these powerful synthetic water channels into RO membrane or making of novel types of water channel-containing non-RO membrane for water purification purpose, which could form the basis for next-generation water purification technology with less energy consumption and better performance.