Mechanosensitive channels are present in the membranes of bacteria, archaea, and eukarya, sensing touch, hearing and balance, as well as participating in cardiovascular regulation and osmotic homeostasis (e.g. thirst). One such type of mechano-channels found in bacteria is cholesterol-dependent channels, with ion transporting activity increasing with increasing amounts of cholesterol so as to attack the eukaryotic cells that contain cholesterol in the membrane, but not bacterial cells that do not contain cholesterol. Inspired by this, we recently designed and experimentally demonstrated an unprecedented class of mechanosensitive ion channels that perfectly mimic those found in bacterial (See: Nat. Commun. 2022, 13, 5985). This field, which thus far has remained limitedly studied, is worth further and systematic investigations in the future.